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Updated: Jun 11, 2026

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
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Rapid intradermal delivery of liquid formulations using a hollow microstructured array.

Scott A Burton1, Chin-Yee Ng, Ryan Simmers

  • 13M Drug Delivery Systems Division, Building 260-03-A-05, St. Paul, Minnesota 55114, USA.

Pharmaceutical Research
|June 29, 2010
PubMed
Summary

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This study shows that 3M

Area of Science:

  • Dermatology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Transdermal drug delivery systems offer a non-invasive alternative to traditional administration routes.
  • Challenges exist in delivering larger volumes and specific drug types intradermally.
  • Microneedle technology presents a potential solution for enhanced transdermal delivery.

Purpose of the Study:

  • To demonstrate the capability of a hollow microneedle delivery device for rapid, self-administered intradermal delivery of up to 1.5 mL of formulation.
  • To assess the feasibility of delivering various drug types, including small molecules and proteins, via this system.

Main Methods:

  • Utilized 3M's hollow Microstructured Transdermal System (hMTS) on domestic swine.
  • Delivered diverse formulations (small molecule salts, proteins) and volumes up to 1.5 mL.

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  • Analyzed plasma concentrations (HPLC/ELISA) for pharmacokinetic (PK) profiling and evaluated skin tolerability post-delivery.

    • Main Results:

    • Successfully infused up to 1.5 mL of formulation at rates up to 0.25 mL/min.
    • Observed transient, mild skin redness post-application that resolved within 10 minutes.
    • Achieved PK profiles comparable to subcutaneous injections for delivered drugs like naloxone hydrochloride and human growth hormone.

    Conclusions:

    • 3M's hMTS facilitates rapid intradermal delivery of 300-1,500 µL liquid formulations.
    • The system is suitable for small molecules and proteins not typically amenable to passive transdermal delivery.
    • Demonstrates potential for self-application of larger volume intradermal injections.