Related Experiment Videos
[Alinidine in multi-vessel coronary disease: reduction of stress-induced ischemic reaction]
H Ditter1, K D Müller, H Bahavar
1Abt. Kardiologie, Kerckhoff-Klinik, Bad Nauheim.
Insights
Alinidine, a bradycardiac agent, reduced resting heart rate and myocardial oxygen demand in patients with coronary artery disease. It also lessened exercise-induced ST-segment depression, suggesting anti-ischemic effects.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Coronary artery disease (CAD) poses significant cardiovascular risks.
- Evaluating novel therapeutic agents for managing ischemic heart conditions is crucial.
Purpose:
- To assess the hemodynamic and electrocardiographic effects of alinidine in patients with established coronary artery disease.
Summary:
- Ten patients with two- or three-vessel CAD underwent a bicycle stress test post-intravenous alinidine administration.
- Alinidine significantly decreased resting heart rate, double product, myocardial oxygen consumption, and cardiac output.
- During exercise, alinidine reduced ST-segment depression and pulmonary artery pressure rise, without impacting peak heart rate.
Impact:
- Alinidine demonstrates potential anti-ischemic properties beyond its bradycardiac effects.
- Findings suggest alinidine may offer a therapeutic benefit in managing myocardial ischemia in CAD patients.
Abstract:
Ten patients suffering from an angiographically documented coronary two- or three-vessel disease were examined to evaluate the effects of the specific bradycardiac agent alinidine during a bicycle stress test. Hemodynamic and electrocardiographic parameters were compared before and after an intravenous application of 30 mg of the substance. The alinidine plasma levels 30 min after the injection were 160.6 +/- 22.5 ng/ml) (mean +/- SEM). Alinidine significantly (p less than 0.05) reduced the resting levels of heart rate (8.5%), double product (10.3%), myocardial oxygen consumption (9.1%), and cardiac output (9.0%). During exercise, significantly less ST-segment depression (p less than 0.001) in the EKG was observed after alinidine application in nine out of 10 patients, and the rise of pulmonary artery pressure was significantly reduced (34.7 vs 38.1 mm Hg, mean p less than 0.05). However, alinidine had no effect on the maximum heart rate at the end of exercise. We, therefore, assume that the substance has additional anti-ischemic properties.