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Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

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Related Experiment Video

Updated: Jun 11, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Pathogenesis of diffuse large B cell lymphoma.

Wing John C Chan1

  • 1Pathology and Microbiology and Center for Leukemia and Lymphoma Research, University of Nebraska Medical Center, Omaha, NE 68198, USA. jchan@unmc.edu

International Journal of Hematology
|June 29, 2010
PubMed
Summary
This summary is machine-generated.

Recent advances reveal distinct diffuse large B cell lymphoma (DLBCL) subtypes based on gene expression and genetic profiles. Targeted therapies and understanding the tumor microenvironment are crucial for improved DLBCL treatment strategies.

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

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Last Updated: Jun 11, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

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Published on: February 12, 2022

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Diffuse large B cell lymphoma (DLBCL) pathogenesis understanding has significantly advanced.
  • Gene expression profiling (GEP) has identified distinct DLBCL subtypes with unique genetic abnormalities.
  • Correlating genetic and GEP data aids in identifying target genes within copy number abnormality regions.

Purpose of the Study:

  • To elucidate the molecular underpinnings of DLBCL subtypes.
  • To highlight the role of the tumor microenvironment in DLBCL.
  • To emphasize the emerging role of microRNA in lymphomagenesis.

Main Methods:

  • Gene expression profiling (GEP) for subtype classification.
  • Analysis of genetic abnormalities and copy number data.
  • Investigation of oncogenic pathway activation.
  • Assessment of the tumor microenvironment's impact.
  • Evaluation of microRNA roles and gene mutations.

Main Results:

  • Distinct DLBCL subtypes exhibit differential oncogenic pathway activation.
  • The tumor microenvironment significantly influences patient outcomes.
  • MicroRNA dysregulation and key gene mutations drive NF-kappaB and B cell receptor signaling.
  • Convergence of genome-wide studies and high-throughput sequencing accelerates discovery.

Conclusions:

  • DLBCL subtypes necessitate targeted therapeutic approaches.
  • The tumor microenvironment presents a potential novel therapeutic target.
  • MicroRNAs and specific gene mutations are critical in DLBCL development.
  • Future research will benefit from integrated multi-omics data and advanced sequencing technologies.