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Updated: Jun 11, 2026

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Helicobacter pylori and gastric cancer
Asma Ouakaa-Kchaou1, Hella Elloumi, Dalila Gargouri
1Department of Gastroenterology, Habib Thameur Hospital, Tunis - Tunisia.
Background:
Patients infected with Helicobacter pylori, a stomach colonizing bacteria, have an increased risk of developing gastric malignancies, in particular gastric carcinomas.
Aim:
This review was aimed to analyze the relationship between gastric carcinoma and Helicobacter pylori infection and to rule out the possibility of preventive measures.
Methods:
To identify articles for this review, a PubMed search was conducted using the following key words: gastric cancer, Helicobacter pylori.
Results:
The risk for developing cancer includes environmental, host-genetic and bacterial factors, which induce physiologic and histologic changes in the stomach. There are two major pathways for the development of gastric cancer by helicobacter pylori: the indirect action on gastric epithelial cells through inflammation leading to gastric atrophy and intestinal metaplasia and the direct action through the induction of protein modulation and gene mutation.
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