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Acute necrotizing encephalopathy during novel influenza A (H1N1) virus infection

Paolo Mariotti1, Raffaele Iorio, Giovanni Frisullo

  • 1Department of Medical and Surgical Pediatric Sciences and Developmental Neurosciences, Unit of Child Neuropsychiatry, Catholic University, Largo Gemelli 8, Rome, Italy.

Annals of Neurology
|June 29, 2010
PubMed

Insights

A novel swine-origin influenza A (H1N1) virus caused acute necrotizing encephalopathy in a child. This rare neurological complication highlights the H1N1 virus

Area of Science:

  • Neurology
  • Virology
  • Pediatrics

Background:

  • A novel swine-origin influenza A (H1N1) virus emerged recently.
  • Neurological complications associated with H1N1 virus infections have been reported.

Observation:

  • A 2-year-old European girl presented with fever, seizures, and altered mental status.
  • Magnetic resonance imaging revealed bilateral symmetrical lesions in the brain and spinal cord.

Findings:

  • The patient was diagnosed with acute necrotizing encephalopathy.
  • Imaging findings were suggestive of acute necrotizing meningoencephalomyelitis, involving the meninges and spinal cord.

Implications:

  • This case underscores the potential for severe neurological manifestations of the novel H1N1 influenza A virus.
  • Further research is needed to understand the pathogenesis of H1N1-associated encephalopathy.

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