Related Experiment Video
Updated: Jul 5, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
Published on: June 13, 2014
[A low-molecular polypeptide of the blood serum in warm-blooded animals: its effect on cell adhesion and
Abstract:
The review deals with investigation of a 6-kDa polypeptide discovered in blood whey of warm-blooded animals. This polypeptide stimulates cell adhesion, the action being characterized by absence of tissue and species specificity. Dose dependence of biological effect, intensively is revealed: optimal are concentrations of 10(-15)--10(-19)m, at which the polypeptide stimulates in-culture fibroblast proliferation. Information is provided about biochemical investigation of the polypeptide: method of its extraction from the whey and of purification; physicochemical properties of the polypeptide extracted from blood whey of various animals and man. For one of the cattle, amino acid composition is determined. Polypeptide states in blood whey at different ontogenetic stages are studied. At earlier stages, the polypeptide is "active"; at later stages of prenatal and in postnatal development, it is "nonactive" due to its being bound by another whey substance, a "carrier". By sum of results of investigation of its physicochemical properties and biological activity, the polypeptide represents previously unstudied blood whey factor.
Related Concept Videos
Overview of Cell-Matrix Interactions
Intracellular Signaling Affects Focal Adhesions
Some...
Cell Adhesion Molecules - Types and Functions
CAM Families
The Integrin family of proteins is primarily involved in a...
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions
CAM Families
The Integrin family of proteins is primarily involved in a...
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...

