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Related Concept Videos

Flow Cytometry01:23

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
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Published on: March 13, 2017

Microfluidic impedance-based flow cytometry.

Karen C Cheung1, Marco Di Berardino, Grit Schade-Kampmann

  • 1Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada. kcheung@ece.ubc.ca

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
|June 29, 2010
PubMed
Summary
This summary is machine-generated.

Microfabricated flow cytometers offer portable, label-free cell analysis using microfluidics and impedance. These systems provide high-content data for distinguishing cell types, impacting diagnostics and research.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Cell Biology

Background:

  • Flow cytometry is crucial for cell analysis.
  • Conventional systems are often complex and costly.
  • Microfluidic systems offer potential for simplified, portable solutions.

Purpose of the Study:

  • To develop microfabricated flow cytometers for label-free cell characterization.
  • To leverage microfluidics and impedance measurements for multiparametric cell analysis.
  • To enhance sensitivity and robustness in chip-based cytometry.

Main Methods:

  • Utilizing microfluidics for sample handling and cell focusing.
  • Employing multifrequency impedance measurements for cell characterization.
  • Integrating microscale flow phenomena for improved cell positioning.

Main Results:

  • Demonstrated analysis of various cell types including microorganisms, erythrocytes, and leukocytes.
  • Achieved high-content data through multiparametric impedance measurements.
  • Developed robust designs enabling cell focusing at high flow rates.

Conclusions:

  • Microfluidic impedance-based flow cytometers provide a simple, low-cost, and portable alternative.
  • Chip-based cytometry excels in analyzing single cells within small populations.
  • These systems have significant potential for point-of-care diagnostics and research applications.