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Biomimetics for the induction of bone formation
1Medical Research Council/University of the Witwatersrand, Johannesburg, 2193 Parktown, South Africa. ugo.ripamonti@wits.ac.za
Abstract:
The new strategy to initiate the induction of bone formation is to carve smart, self-inducing geometric cues assembled within biomimetic medical devices. These are endowed with the striking prerogative of differentiating myoblastic and/or pericytic stem cells into osteoblastic-like cells attached to the morphogenetic concavities; osteoblastic-like cells secrete osteogenic gene products of the TGF-beta supergene family, further differentiating invading stem cells into osteoblastic-like cells, and initiating bone formation by induction as a secondary response.
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