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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Multifocal chorangiomatosis.

Christina Bagby1, Raymond W Redline

  • 1Department of Pathology, University Hospitals Case Medical Center, Cleveland, OH, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|June 30, 2010
PubMed
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Multifocal chorangiomatosis (MC), a placental vascular lesion, is more common in preterm infants and associated with congenital anomalies. Extensive MC links to stillbirth and large for gestational age infants, while patchy MC is linked to small for gestational age infants.

Area of Science:

  • Perinatology
  • Pathology
  • Obstetrics

Background:

  • Multifocal chorangiomatosis (MC) is an infrequent villous capillary lesion of the placenta.
  • It shares characteristics with villous chorangiosis and placental chorangioma.

Purpose of the Study:

  • To prospectively identify cases of multifocal chorangiomatosis (MC) in placentas.
  • To analyze associated clinical and pathological features through a case-control study.
  • To investigate the relationship between MC extent and fetal outcomes.

Main Methods:

  • Prospective identification of 53 MC cases from 5429 placentas (>20 weeks gestation) over 10 years.
  • Selection of two gestational age-matched controls per case.
  • Case-control analysis of clinical and pathological findings, including MC subcategorization (extensive vs. patchy).

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Main Results:

  • MC occurred across all gestational ages, most frequently in preterm placentas (<32 weeks).
  • Associated placental findings included avascular villi, villous chorangiosis, distal villous immaturity, arteriolar narrowing, edema, and dysmorphic villi.
  • Infants with placental MC showed a higher prevalence of congenital anomalies; extensive MC correlated with congenital anomalies, stillbirth, and large for gestational age, while patchy MC correlated with small for gestational age.

Conclusions:

  • Multifocal chorangiomatosis (MC) is linked to advanced maternal age, non-African-American ancestry, nonprimigravid status, and multiparity.
  • Placental MC is associated with an increased risk of congenital anomalies.
  • MC may arise from abnormal capillary proliferation related to fetoplacental development and blood flow anomalies.