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Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
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Results from a mathematical model for human monocytic ehrlichiosis

H Gaff1, L Gross, E Schaefer

  • 1Analysis and Simulation Center, School of Community and Environmental Health College of Health Sciences, Old Dominion University, Norfolk, VA 23529, USA. hgaff@odu.edu

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|June 30, 2010
PubMed
Abstract

No abstract available in PubMed .

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The linear concentration–effect model, underpinned by the principle that pharmacological effect (E) is directly proportional to plasma drug concentration (C), emerges as a pivotal simplification of the Emax model for conditions where C is significantly less than EC50. This model portrays a linear trajectory of the concentration–effect relationship when drug levels are markedly below the EC50 threshold.Despite its inherent assumption of continuous effect augmentation with increasing drug...
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