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Related Experiment Video

Updated: Jun 11, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Thromboangiitis obliterans and endothelial function.

Michel Azizi1, Pierre Boutouyrie, Alessandra Bura-Rivière

  • 1Université Paris Descartes, Faculté de Médecine, Paris, France. michel.azizi@egp.aphp.fr

European Journal of Clinical Investigation
|June 30, 2010
PubMed
Summary
This summary is machine-generated.

Thromboangiitis obliterans (TAO) patients exhibit vasoconstriction and increased aortic stiffness during exacerbations. Endothelial function, measured by flow-mediated dilation, remains unchanged in acute TAO.

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Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

Related Experiment Videos

Last Updated: Jun 11, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

Area of Science:

  • Vascular Biology
  • Cardiovascular Physiology
  • Rheumatology

Background:

  • Endothelial dysfunction is a potential factor in the pathophysiology of thromboangiitis obliterans (TAO).
  • This study investigates endothelial function and arterial stiffness in TAO patients during exacerbation.

Purpose of the Study:

  • To compare endothelial function and large artery stiffness between TAO patients in exacerbation and healthy controls.
  • To elucidate the role of endothelial dysfunction in acute TAO.

Main Methods:

  • Assessed flow-mediated vasodilation via gradual hand skin heating and endothelium-independent vasodilation using glyceryl trinitrate (GTN).
  • Utilized high-resolution echotracking to measure brachial artery (BA) diameter and wall shear stress.
  • Measured aortic stiffness using carotid-to-femoral pulse wave velocity.

Main Results:

  • TAO patients had a smaller baseline brachial artery diameter compared to controls (P=0.04).
  • No significant difference in flow-mediated dilation was observed between TAO patients and controls.
  • TAO patients demonstrated significantly greater endothelium-independent vasodilation after GTN (P=0.02) and increased aortic stiffness (P=0.0052).

Conclusions:

  • Acute thromboangiitis obliterans is characterized by vasoconstriction and elevated aortic stiffness.
  • Flow-mediated dilation is not altered in the exacerbation phase of TAO, suggesting preserved endothelium-dependent vasodilation.
  • Increased arterial stiffness may contribute to the vascular complications observed in TAO.