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Photopatch testing negative in systemic quinine phototoxicity
Alastair Kerr1, Mohammed Shareef, Robert Dawe
1Photobiology Unit, Ninewells Hospital, Dundee, Angus, UK. a.kerr@dundee.ac.uk
Photodermatology, Photoimmunology & Photomedicine
|June 30, 2010
Summary
Photopatch testing for drug-induced phototoxicity to quinine sulfate was not useful in three patients. This diagnostic method did not yield positive results for identifying this specific drug reaction.
Area of Science:
- Dermatology
- Photodermatology
Background:
- Drug-induced phototoxicity is a reaction to systemic or topical agents.
- Photopatch testing is standard for photocontact allergic dermatitis but unvalidated for drug-induced phototoxicity.
Purpose of the Study:
- To evaluate the utility of photopatch testing for diagnosing drug-induced phototoxicity from quinine sulfate.
Main Methods:
- Retrospective analysis of photopatch test results in three patients diagnosed with quinine sulfate-induced phototoxicity.
Main Results:
- None of the three patients exhibited positive photopatch test reactions to quinine sulfate at any time point.
- Photopatch testing did not provide additional diagnostic value for drug-induced phototoxicity in these cases.
Conclusions:
- Photopatch testing to quinine sulfate is not a useful investigation for diagnosing drug-induced phototoxicity in patients presenting with this condition.
