Related Experiment Video
Updated: Jun 11, 2026
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
Preferential induction of endothelin-1 in a human epidermal equivalent model by narrow-band ultraviolet B light
Reiko Noborio1, Akimichi Morita
1Department of Geriatric and Environmental Dermatology, Nagoya City University of Medical Sciences, Nagoya, Japan. noborior@hirakata.kmu.ac.jp
Abstract:
Narrow-band ultraviolet B (NB-UVB; 310-315 nm) is commonly used to treat vitiligo, but the mechanisms underlying the therapeutic effect have not been understood completely. Here, we evaluated the effects of broadband UVB (BB-UVB), NB-UVB, 308 nm xenon chloride (XeCl) excimer laser, and 308 nm XeCl excimer light on the expression of endothelin-1 (ET-1) in a cultured human epidermal tissue model. Our results provide a theoretical basis for the effectiveness of UVB irradiation, including excimer light and excimer laser, in the treatment of vitiligo.
