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Influence of no-donor (SIN-1) on functions of inflammatory cells
A Dembińska-Kieć1, A Zmuda, J Marcinkiewicz
1Chair of Pharmacology, Institute of Microbiology Copernicus Academy of Medicine, Cracow, Poland.
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|January 1, 1991
Abstract:
NO-donor SIN-1 (0.01-1.0 mM) dose-dependently inhibited the basal and FMLP (30.0 mM)-stimulated release of beta-glucuronidase from rat peritoneal leukocytes and antigen-specific stimulation of Interleukin-2 production by T-hybridomas. I-123 LDL binding to human lymphocytes was inhibited by Iloprost (1 mM) but activated by SIN-1 (0.3 mM). We conclude that beside the smooth muscle cells and platelets the blood inflammatory/immune cells are under the PGI2/NO control, however, the precise regulation as well as physiological importance need further investigation.