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Updated: Jun 11, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
[Risk factors for cerebral microbleeds]
1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. aka_gz@126.com
Objective:
To analyze the risk factors of cerebral microbleeds (CMBs).
Methods:
A total of 113 patients with cerebrovascular diseases underwent examinations of magnetic resonance imaging (MRI) of the brain (including T1WI, T2WI, FLAIR, and SWI) and blood biochemical tests, and the brain regions, number and grades of the CMBs were analyzed. The association between CMBs and the cardiovascular risk factors were analyzed.
Results:
A The occurrence and grade of CMBs were associated with the patients' age, hypertension, diabetes, lacunar infarction, diastolic blood pressure, systolic blood pressure and high-density lipoprotein (HDL) levels (P<0.05). CMB occurrence was significantly associated with diabetes, hypertension, and lacunar infarction (P<0.05), and its incidence varied significantly between different brain regions (P<0.05).
Conclusion:
Age, hypertension, diabetes, lacunar infarction, diastolic blood pressure, systolic blood pressure, and HDL are all risk factors for CMBs, among which diabetes, hypertension, and lacunar infarction are significant risk factors. CMBs occurs most frequently in the cortex and subcortical region, followed by the basal ganglia, thalamus, and the cerebellum, and most unlikely in the brainstem.
Insights
Age, hypertension, diabetes, and lacunar infarction are key risk factors for cerebral microbleeds (CMBs). These conditions, along with blood pressure and HDL levels, significantly influence CMB occurrence and severity.
Area of Science:
- Neurology
- Radiology
- Biochemistry
Context:
- Cerebral microbleeds (CMBs) are increasingly recognized markers of cerebrovascular disease.
- Understanding CMBs' risk factors is crucial for predicting and preventing neurological events.
Purpose:
- To identify and analyze the risk factors associated with the occurrence and severity of cerebral microbleeds (CMBs).
Summary:
- This study analyzed MRI scans and blood tests from 113 patients with cerebrovascular diseases.
- Results indicate that age, hypertension, diabetes, lacunar infarction, blood pressure, and HDL levels are associated with CMBs.
- Diabetes, hypertension, and lacunar infarction were identified as significant risk factors, with CMBs most common in the cortex and subcortical regions.
Impact:
- Identifies critical risk factors for cerebral microbleeds, aiding in targeted prevention strategies.
- Highlights the importance of managing hypertension and diabetes to reduce CMB risk.
- Provides insights into the topographical distribution of CMBs within the brain.
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