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Vitreoschisis in macular diseases
Priya Gupta1, Kenneth M P Yee, Patricia Garcia
1VMR Institute, 7677 Center Avenue, Suite 400, Huntington Beach, CA 92647, USA.
The British Journal of Ophthalmology
|June 30, 2010
Summary
Vitreoschisis, a split in the posterior vitreous cortex, was found in about half of eyes with macular holes and macular pucker. This suggests vitreoschisis may play a role in these macular diseases.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vitreoretinal Interface
Background:
- Vitreoschisis, a splitting of the posterior vitreous cortex, is a potential factor in macular diseases.
- The vitreoretinal interface is crucial for understanding macular pathology.
Purpose of the Study:
- To investigate the presence and significance of vitreoschisis in various macular diseases.
- To determine if vitreoschisis is specifically associated with macular holes (MH) and macular pucker (MP).
Main Methods:
- Histopathological analysis of monkey eyes and a human macular pucker specimen.
- Optical coherence tomography/scanning laser ophthalmoscopy (OCT/SLO) imaging in 239 eyes across different macular conditions and controls.
Main Results:
- Vitreoschisis was detected in 53% of MH and 42% of MP eyes, significantly higher than in controls (7%), dry age-related macular degeneration (AMD) (6%), and non-proliferative diabetic retinopathy (NPDR) (13%).
- Evidence of posterior vitreous cortex splitting and rejoining was confirmed through histopathology and OCT/SLO imaging.
Conclusions:
- Vitreoschisis is significantly more prevalent in eyes with MH and MP compared to other maculopathies and healthy controls.
- Anomalous posterior vitreous detachment (PVD) associated with vitreoschisis is implicated as a pathogenic mechanism in MH and MP.
