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Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
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Transport of premature infants is associated with increased risk for intraventricular haemorrhage

Mohamed A Mohamed1, Hany Aly

  • 1Newborn Services Department, The George Washington University Medical Center, Washington, DC 20037, USA. mmohamed@mfa.gwu.edu

Archives of Disease in Childhood. Fetal and Neonatal Edition
|June 30, 2010
PubMed

Insights

Inter-hospital transport of very low birth weight (VLBW) infants is linked to a higher incidence and severity of intraventricular haemorrhages (IVH). This association remained consistent over the study period, highlighting transport risks for vulnerable newborns.

Area of Science:

  • Neonatalogy
  • Perinatal Medicine
  • Clinical Epidemiology

Background:

  • Intraventricular haemorrhages (IVH) significantly impact outcomes for very low birth weight (VLBW) infants.
  • Understanding risk factors for IVH is crucial for improving neonatal care.

Purpose of the Study:

  • To examine the correlation between inter-hospital transport and the incidence and severity of IVH in VLBW infants.
  • To analyze trends in IVH and neonatal transport over time.

Main Methods:

  • Analysis of the US National Inpatient Sample Database (NIS) from 1997-2004.
  • Inclusion of VLBW infants (<1500 g), categorized into transport and inborn groups.
  • Logistic regression models used to calculate adjusted odds ratios (OR) for IVH, controlling for confounders.

Main Results:

  • A total of 67,596 VLBW infants were studied.
  • The transport group showed a higher incidence of IVH (27.4% vs 13.42%) and severe IVH (44.1% vs 32.9%) compared to the inborn group.
  • Adjusted ORs indicated a significant correlation between transport and increased risk of IVH (OR 1.75) and severe IVH (OR 1.44).

Conclusions:

  • Inter-hospital transport of VLBW infants is associated with increased incidence and severity of IVH.
  • This correlation has remained constant over recent years.
  • Neonatal transport and IVH incidence have both shown increasing trends over time.
Abstract

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