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Single Molecule Fluorescence Energy Transfer Study of Ribosome Protein Synthesis
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Joining the interface: a site for Nmd3 association on 60S ribosome subunits

Marlene Oeffinger1

  • 1Laboratoire de Biochimie des ribonucléoprotéines, Institut de recherches cliniques de Montréal, Montréal, Québec H2W 1R7, Canada. marlene.oeffinger@ircm.qc.ca

The Journal of Cell Biology
|June 30, 2010
PubMed

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Ribosomes01:27

Ribosomes

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Ribosomes01:27

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Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
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Ribosomes01:27

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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...