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Effects of glutamine on glycemic control during and after exercise in adolescents with type 1 diabetes: a pilot study
Nelly Mauras1, Dongyuan Xing, Larry A Fox
1Division of Endocrinology, Diabetes and Metabolism, Nemours Children's Clinic, Jacksonville, Florida, USA. nmauras@nemours.org
Objective:
To investigate if oral glutamine ameliorates exercise and postexercise nighttime hypoglycemia in type 1 diabetic adolescents.
Research Design And Methods:
Ten adolescents (15.2 +/- 1.4 years [SD], A1C 6.9 +/- 0.9%) on insulin pumps were studied. The subjects were randomized to receive a glutamine or placebo drink pre-exercise and at bedtime (0.25 g/kg/dose). A 3:00 p.m. exercise session consisted of four 15-min treadmill/5-min rest cycles. Pre-exercise blood glucose was 140-150 mg/dl and was monitored throughout the night. Studies were randomized crossover over 3 weeks.
Results:
Blood glucose levels dropped comparably (52%) during exercise on both days. However, the overnight number of hypoglycemic events was higher on glutamine than placebo (
Conclusions:
Glutamine increased the cumulative probability of postexercise overnight hypoglycemia compared with placebo in adolescents with type 1 diabetes. Whether glutamine may enhance insulin sensitivity postexercise requires further study in type 1 diabetes.
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