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Related Experiment Video

Updated: Jun 11, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Mouse models for blistering skin disorders.

Radhika Ganeshan1, Jiangli Chen, Peter J Koch

  • 1Department of Dermatology, University of Colorado Medical School, 12800 East 19th Avenue, Aurora, CO 80045, USA.

Dermatology Research and Practice
|June 30, 2010
PubMed
Summary
This summary is machine-generated.

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Experimental dermatology·2023

Genetically engineered mice lacking desmoglein 3 or desmocollin 3 reveal insights into desmosome function and blistering skin diseases like pemphigus vulgaris.

Area of Science:

  • Cell Biology
  • Dermatology
  • Genetics

Background:

  • Genetically engineered mice are crucial for studying human disease mechanisms.
  • Impaired desmosome function causes various blistering skin diseases.
  • Desmosomal cadherins, like desmoglein 3 and desmocollin 3, are vital for epithelial integrity.

Purpose of the Study:

  • To review genetically engineered mouse models lacking desmoglein 3 or desmocollin 3.
  • To compare the resulting phenotypes and their relevance to human diseases.
  • To discuss the utility and limitations of these mouse models for understanding blistering skin diseases.

Main Methods:

  • Focus on mouse models with genetic alterations in desmoglein 3 or desmocollin 3.
  • Comparative analysis of observed phenotypes in different mouse lines.

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  • Correlation of mouse model phenotypes with human disease manifestations.

    • Main Results:

    • Mice lacking desmoglein 3 or desmocollin 3 exhibit distinct blistering skin phenotypes.
    • These models establish a link between specific desmosomal gene mutations and disease.
    • Phenotypes provide insights into the role of desmosomes in epithelial barrier function.

    Conclusions:

    • Genetically engineered mice are valuable tools for dissecting desmosome-related diseases.
    • These models facilitate understanding of pemphigus vulgaris and other blistering conditions.
    • Further research using these models can advance therapeutic strategies for skin diseases.