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Radiation therapy for B-cell cutaneous lymphoid hyperplasia.

Robert B Taylor¹, John A Fortney, Ross B Pollack

¹Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC 29403, USA. taylorro@musc.edu

Japanese Journal of Radiology

|June 30, 2010

Summary

B-cell cutaneous lymphoid hyperplasia (BCCLH) can progress to lymphoma. Aggressive radiotherapy effectively treated a patient resistant to other therapies, showing long-term remission with manageable side effects.

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Area of Science:

Dermatology
Oncology
Radiation Oncology

Background:

B-cell cutaneous lymphoid hyperplasia (BCCLH) is recognized as a pre-malignant condition within the spectrum of B-cell lymphoproliferative disorders.
BCCLH can potentially progress to primary cutaneous B-cell lymphoma (CBCL), necessitating effective treatment strategies.
Limited outcome data are available for BCCLH cases resistant to conventional therapies.

Observation:

A case study involving a 63-year-old female patient with BCCLH is presented.
The patient had previously undergone immunomodulatory treatment without success.
The patient received an aggressive course of radiotherapy as a subsequent treatment option.

Findings:

The patient was treated with 18 fractions of 6 MeV electron beam therapy, delivering 200 cGy per fraction.

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Following radiotherapy, the patient achieved a 3-year recurrence-free survival.

Acute toxicity was observed as Radiation Therapy Oncology Group grade II skin toxicity, which resolved within one month post-treatment.

Implications:

Definitive radiotherapy can be a viable and effective treatment for refractory B-cell cutaneous lymphoid hyperplasia.
Aggressive radiotherapy demonstrates potential for long-term remission in BCCLH patients.
Radiotherapy offers a manageable toxicity profile for treating BCCLH, even in treatment-resistant cases.