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Pseudoangiomatous stromal hyperplasia: an overview
1Department of Pathology, UMass Memorial Medical Center, University of Massachusetts School of Medicine, Three Biotech, One Innovation Drive, Worcester, MA 01605, USA.
Archives of Pathology & Laboratory Medicine
|July 1, 2010
Summary
Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast condition often found incidentally. Tumorous PASH presents as a mass, treated with surgery, offering an excellent prognosis.
Area of Science:
- Breast Pathology
- Mesenchymal Lesions
- Hormonal Etiology
Background:
- Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion.
- It is a proliferative mesenchymal lesion with a potential hormonal cause.
- PASH commonly affects women of reproductive age.
Purpose of the Study:
- To describe the characteristics of pseudoangiomatous stromal hyperplasia (PASH).
- To differentiate PASH from malignant breast lesions.
- To outline management and prognosis for PASH.
Main Methods:
- Histopathological examination of breast biopsies.
- Gross and microscopic analysis of PASH.
- Immunohistochemical staining for specific markers (progesterone receptors, vimentin, actin, CD34).
Main Results:
- PASH presents as slit-like spaces within dense stroma, lined by myofibroblasts.
- Tumorous PASH appears as a well-circumscribed, firm mass.
- Immunohistochemistry shows spindle cells positive for progesterone receptors, vimentin, actin, and CD34.
Conclusions:
- Incidental PASH requires no specific treatment.
- Tumorous PASH is managed with surgical excision.
- Prognosis for treated tumorous PASH is excellent with low recurrence risk.
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