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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Genetic Lingo01:11

Genetic Lingo

Overview

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Related Experiment Video

Updated: Jun 11, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Genetics of dementia.

M B Russell1

  • 1Head and Neck Research Group, Research Centre, Akershus University Hospital, Oslo, Norway. m.b.russell@medisin.uio.no

Acta Neurologica Scandinavica. Supplementum
|July 1, 2010
PubMed
Summary

Alzheimer's disease and dementia have genetic links, including inherited forms and risk factors like APOE. Genes such as CLU, PICALM, and CRI are also implicated in late-onset Alzheimer's disease.

Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Dementia is a syndrome encompassing various conditions, including Alzheimer's disease (AD).
  • Early-onset AD can be autosomal dominant (APP, PSEN1, PSEN2 mutations), while late-onset AD involves complex inheritance.
  • Stroke is also a syndrome, with CADASIL (NOTCH3 mutations) being a primary inherited cause of stroke and vascular dementia.

Purpose of the Study:

  • To explore the genetic underpinnings of dementia and Alzheimer's disease.
  • To identify genetic risk factors and protective elements for late-onset Alzheimer's disease.
  • To understand the relationship between stroke, vascular dementia, and genetic mutations.

Main Methods:

  • Review of population-based twin studies for late-onset AD inheritance patterns.

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Last Updated: Jun 11, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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  • Analysis of genome-wide association studies (GWAS) to identify AD-associated genes.
  • Examination of genetic mutations linked to inherited stroke and vascular dementia (e.g., CADASIL).

    • Main Results:

    • APOE epsilon4 is a significant risk factor for late-onset AD; epsilon2 offers protection.
    • GWAS identified CLU, PICALM, and CRI as important genes for late-onset AD.
    • NOTCH3 gene mutations cause CADASIL, a major inherited cause of stroke and vascular dementia.

    Conclusions:

    • Genetic factors play a crucial role in both early and late-onset Alzheimer's disease.
    • Understanding these genetic links is vital for diagnosing and potentially treating dementia and AD.
    • Stroke-induced dementia highlights the critical link between cerebrovascular events and cognitive decline.