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Updated: Jun 11, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Coronary revascularisation in chronic kidney disease. Part 1: stable coronary artery disease
1Wessex Cardiac Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton, SO16 6YD, UK.
Insights
Patients with chronic kidney disease (CKD) face high risks of heart issues. This review examines coronary artery disease treatments, including revascularization, for CKD patients.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Background:
- Chronic kidney disease (CKD) significantly increases the risk of coronary artery disease (CAD), myocardial infarction, and cardiovascular mortality.
- Managing CAD in CKD patients is challenging due to screening test limitations, scarce evidence on interventions, and concerns about adverse effects.
Purpose of the Study:
- To review current evidence on treating coronary artery disease in patients with chronic kidney disease.
- To focus on the role of coronary revascularization strategies, including percutaneous coronary intervention and coronary artery bypass grafting, in this population.
Main Methods:
- Systematic review of existing literature on CAD treatment in CKD patients.
- Analysis of evidence concerning percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) outcomes.
Main Results:
- CKD patients with CAD may benefit from conventional treatment strategies despite existing challenges.
- Evidence regarding the efficacy and safety of revascularization procedures in CKD requires further investigation.
Conclusions:
- Coronary revascularization via PCI or CABG is a potential treatment for CAD in CKD patients.
- Further research is needed to establish optimal therapeutic approaches and mitigate risks in this vulnerable population.
Abstract:
Chronic kidney disease (CKD) is associated with a high burden of coronary artery disease, myocardial infarction and cardiovascular death. Detection and treatment of coronary artery disease in CKD patients has been hampered by the limitations of screening tests, the lack of direct evidence for therapeutic interventions in this specific population, and concerns about therapy-related adverse effects. However, these patients potentially have much to gain from conventional strategies used in the general population. This review summarises the current evidence regarding the treatment of coronary artery disease in patients with CKD, with the focus on coronary revascularisation by percutaneous coronary intervention or coronary artery bypass grafting.
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