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Blood-induced joint disease: the pathophysiology of hemophilic arthropathy

L A Valentino1

  • 1Rush Hemophilia and Thrombophilia Center, Department of Pediatrics, Rush Children's Hospital and Rush University Medical Center, Chicago, IL USA. lvalentino@rush.edu

Journal of Thrombosis and Haemostasis : JTH
|July 1, 2010
PubMed

Arthropathy is a frequent and serious complication of repeated joint bleeding in patients with hemophilia, resulting in pain, deformity, and disability. Although the pathogenesis of hemophilic arthropathy has not been fully elucidated, it appears to have similarities with the degenerative joint damage that occurs in osteoarthritis and the inflammatory processes associated with rheumatoid arthritis. This article reviews the potential actions of various blood constituents on joint components that culminate in the development of hemophilic arthropathy.

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