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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Updated: Jun 11, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Cancerous stem cells: deviant stem cells with cancer-causing misbehavior.

Julie M Chandler1, Eric Lagasse

  • 1McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh Medical School, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219, USA. juc24@pitt.edu

Stem Cell Research & Therapy
|July 1, 2010
PubMed
Summary
This summary is machine-generated.

Cancer can start in stem cells, disrupting tissue balance. Targeting cancerous stem cells

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Last Updated: Jun 11, 2026

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Published on: May 11, 2016

Area of Science:

  • Stem cell biology
  • Cancer biology
  • Genomic instability

Background:

  • Stem cells are crucial for tissue homeostasis through self-renewal and differentiation.
  • Dysregulation of stem cell balance can lead to disease, including cancer initiation.
  • Cancerous stem cells exhibit therapy resistance, promoting recurrence and metastasis.

Purpose of the Study:

  • To explore the origins and characteristics of cancerous stem cells.
  • To understand the role of signaling pathways in stem cell transformation.
  • To identify therapeutic strategies targeting cancerous stem cells.

Main Methods:

  • Analysis of stem cell signaling pathways in the gut.
  • Investigation of genomic instability in cancerous stem cells.
  • Evaluation of therapeutic resistance mechanisms.

Main Results:

  • Aberrant signaling pathways can induce cancerous stem cell formation.
  • Genomic instability confers an adaptive advantage to cancerous stem cells under therapy.
  • Cancerous stem cells demonstrate resistance to conventional treatments.

Conclusions:

  • Understanding stem cell alterations is key to new cancer therapies.
  • Targeting cancerous stem cells for differentiation or destruction offers a promising approach.
  • Erradicating cancerous stem cells can improve patient survival and outcomes.