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Related Concept Videos

Differential Staining Technique01:26

Differential Staining Technique

Differential staining is an essential microbiological technique that exploits variations in cell wall structures to classify and identify microorganisms. It facilitates the distinction of bacteria, aiding in diagnostic and research applications. Two of the most widely used differential staining methods are Gram staining and acid-fast staining, both of which rely on the chemical and structural differences in bacterial cell walls.Gram Staining TechniqueGram staining differentiates bacteria by...
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Inhibitors of Gram-positive Cell Wall Synthesis

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Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
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Bacterial Phylum Tenericutes

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Updated: Jun 11, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Think (Gram) negative!

Benedikt Huttner1, Stephan Harbarth

  • 1Infection Control Program, University of Geneva Hospitals and Medical School, CH-1211 Geneva 14, Switzerland. benedikt.huttner@hcuge.ch

Critical Care (London, England)
|July 1, 2010
PubMed
Summary
This summary is machine-generated.

Multiresistant Gram-negative bacteria, like extended-spectrum beta-lactamase-producing Escherichia coli and carbapenem-resistant Klebsiella, are rising in Europe. This surveillance study examines antibiotic use and resistance in German ICUs, highlighting a difficult-to-interrupt cycle.

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Last Updated: Jun 11, 2026

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Rising prevalence of multiresistant Gram-negative bacteria (Enterobacteriaceae family) in Europe.
  • Widespread community presence of extended-spectrum beta-lactamase-producing Escherichia coli, with frequent hospital importation.
  • Growing concern over endemic carbapenem-resistant Klebsiella spp. spread.

Discussion:

  • Antibiotic use is a primary driver of escalating antibiotic resistance.
  • A detrimental cycle exists where resistance necessitates increased broad-spectrum antibiotic use.
  • Commentary focuses on a surveillance study of antimicrobial use and resistance in German ICUs over 8 years.

Key Insights:

  • Surveillance data from German ICUs over 8 years provides critical insights into resistance trends.
  • Focus on Gram-negative resistance patterns within the intensive care unit setting.
  • Analysis links antimicrobial usage patterns to the development and spread of resistance.

Outlook:

  • Need for strategies to interrupt the cycle of antibiotic resistance.
  • Importance of continued surveillance to monitor resistance trends in healthcare settings.
  • Potential implications for infection control and antibiotic stewardship programs.