Related Experiment Video
Updated: Jun 11, 2026
Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography
V Carlin1, A J Artioli, M A Matsumoto
1Departament of Pathology, Paulista Medical School, Federal University of São Paulo, UNIFESP, SP, Brazil.
Objectives:
The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure.
Methods:
A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included.
Results:
No significant statistically differences (P > 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. In contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P < 0.05).
Conclusion:
In summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity.
