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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
Blood pressure course in acute stroke relates to baroreflex dysfunction.
Marek Sykora1, Jennifer Diedler, Sven Poli
1Department of Neurology, University of Heidelberg, Heidelberg, Germany. marek.sykora@med.uni-heidelberg.de
Cerebrovascular Diseases (Basel, Switzerland)
|July 1, 2010
Summary
Impaired baroreflex sensitivity (BRS) is linked to acute hypertension in stroke patients. Lower BRS independently predicts high blood pressure episodes within 72 hours post-stroke, suggesting a potential therapeutic target.
Area of Science:
- Neurology
- Cardiovascular Physiology
Background:
- Acute hypertension is common in stroke and linked to poor outcomes.
- The underlying pathophysiology of acute hypertension in stroke remains unclear.
- Baroreflex dysfunction is frequently observed in stroke patients.
Purpose of the Study:
- To investigate the relationship between baroreflex sensitivity (BRS) and blood pressure (BP) derangements in the acute phase of stroke.
- To determine if impaired BRS predicts acute hypertension in stroke patients.
Main Methods:
- Assessed BRS in 109 acute stroke patients (ischemic and hemorrhagic) using sequential cross-correlation.
- Recorded admission BP and continuous 72-hour BP monitoring.
- Included demographic, clinical data, stroke volumes, and admission NIHSS scores in the analysis.
Main Results:
- Decreased BRS significantly correlated with admission BP and the occurrence of acute hypertension (> or =220/110 mm Hg).
- BRS was also associated with the number of hypertensive episodes within the first 72 hours post-admission.
- BRS was an independent predictor of acute hypertension on admission and within the first 72 hours, independent of stroke volume or NIHSS score.
Conclusions:
- Reduced BRS is independently associated with acute hypertension upon admission for stroke.
- BRS appears to be a reliable predictor of BP trajectory in the initial 72 hours after stroke.
- Therapeutic strategies targeting BRS may hold relevance for managing acute hypertension in stroke, warranting further investigation.
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