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Updated: Jun 11, 2026

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells
Katie Williams1, Katherine Seiss, Jill Beamon
1Ragon Institute of MGH, Harvard, Massachusetts Institute of Technology, Boston, Massachusetts 02114, USA.
Abstract:
Telomerase activity in HIV-1-specific CD8(+) T cells from controllers contributes to the maintenance of highly functional cytotoxic T cell responses against HIV-1. Here, we show that high expression of telomerase in controllers is associated with hypermethylation at the distal and hypomethylation at the proximal human telomerase catalytic subunit promoter, whereas HIV-1-specific CD8(+) T cells from progressors showed an inverse pattern with distal promoter hypomethylation and proximal promoter hypermethylation. These data suggest distinct epigenetic signatures in HIV-1-specific T cells in progressors and controllers.
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