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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
HLA-G*0105N allele is associated with augmented risk for HIV infection in white female patients
Ludovica Segat1, Eulalia Catamo, Annalisa Fabris
1Genetic Service, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. segat@burlo.trieste.it
Abstract:
We analyzed HLA-G 3777G > C, HLA-G 14 bp deletion/insertion and HLA-G*0105N polymorphisms in HIV-positive white adult participants, infected through horizontal heterosexual transmission, and unexposed uninfected individuals, all from north eastern Italy. We report a new association between the HLA-G*0105N allele and HIV infection in adult white female participants, being HLA-G*0105N null allele correlated with an augmented risk (odds ratio = 4.35, 95% confidence interval = 1.38-18.07, P = 0.005) for HIV infection.
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