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Combining Imaging and Electrophysiology to Visualize and Record Spreading Depolarizations in Mice
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Gabapentin suppresses cortical spreading depression susceptibility.

Ulrike Hoffmann1, Ergin Dileköz, Chiho Kudo

  • 1Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|July 1, 2010
PubMed
Summary

Gabapentin elevates the electrical threshold for cortical spreading depression (CSD) and reduces its recurrence in rats. This suggests gabapentin may help suppress brain injury depolarizations in conditions like stroke and TBI.

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