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Updated: Jun 11, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
Published on: March 22, 2012
Temporal-imaging system with simple external-clock triggering
Daniel H Broaddus1, Mark A Foster, Onur Kuzucu
1School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA. dhb29@cornell.edu
Abstract:
We demonstrate a temporal imaging system based on parametric mixing that allows simple triggering from an external clock by using a time-lens-based pump laser. We integrate our temporal imaging system into a time-to-frequency measurement scheme and demonstrate the ability to perform characterization of temporal waveforms with 1.4-ps resolution and a 530-ps record length. We also integrate our system into a temporal-magnification scheme and demonstrate single-shot operation with a 113 x magnification factor, 1.5-ps resolution, and 220-ps record length.

