Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chirality in Nature02:30

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid. The...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
Chirality02:25

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
Radical Halogenation: Stereochemistry01:33

Radical Halogenation: Stereochemistry

Stereochemistry is the study of the different spatial arrangements of atoms in a given molecule. The stereochemistry of radical halogenations can be understood from three different situations:
Halogenation to form a new chiral center:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Behavioral Signatures in a Situational Judgment Test for Criterion B Borderline Pathology: Predicting Criterion A Personality Functioning Beyond Traditional Questionnaire-Based Trait Assessment.

Journal of personality assessment·2026
Same author

How cluster B-related personality traits in mothers shape their ratings of their adolescents' personality: a multisource approach using the Trait-Reputation-Identity model.

Borderline personality disorder and emotion dysregulation·2025
Same author

Daily nonsuicidal self-injury thoughts in emerging adulthood: The relevance of pre-adolescent borderline traits.

Development and psychopathology·2023
Same author

Association of alcohol control policies with adolescent alcohol consumption and with social inequality in adolescent alcohol consumption: A multilevel study in 33 countries and regions.

The International journal on drug policy·2020
Same author

Publisher Correction: Statistics of thermomagnetic breakdown in Nb superconducting films.

Scientific reports·2020
Same author

Molecular understanding of label-free second harmonic imaging of microtubules.

Nature communications·2019

Related Experiment Video

Updated: Jun 11, 2026

Polarization-Sensitive Two-Photon Microscopy for a Label-Free Amyloid Structural Characterization
05:54

Polarization-Sensitive Two-Photon Microscopy for a Label-Free Amyloid Structural Characterization

Published on: September 8, 2023

Linearly polarized second harmonic generation microscopy reveals chirality.

V K Valev, A V Silhanek, N Smisdom

    Optics Express
    |July 1, 2010
    PubMed
    Summary

    Researchers developed a new method to detect material handedness using linearly polarized light and Second Harmonic Generation (SHG) microscopy. This technique analyzes unique hotspots in chiral nanostructures, offering novel insights into artificial material chirality.

    More Related Videos

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation
    10:52

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation

    Published on: February 4, 2017

    Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy
    08:49

    Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy

    Published on: December 1, 2023

    Related Experiment Videos

    Last Updated: Jun 11, 2026

    Polarization-Sensitive Two-Photon Microscopy for a Label-Free Amyloid Structural Characterization
    05:54

    Polarization-Sensitive Two-Photon Microscopy for a Label-Free Amyloid Structural Characterization

    Published on: September 8, 2023

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation
    10:52

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation

    Published on: February 4, 2017

    Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy
    08:49

    Multimodal Nonlinear Hyperspectral Chemical Imaging Using Line-Scanning Vibrational Sum-Frequency Generation Microscopy

    Published on: December 1, 2023

    Area of Science:

    • Optics and Photonics
    • Materials Science
    • Nanotechnology

    Background:

    • Chirality in optics is commonly studied using circularly polarized light.
    • Detecting chirality in artificial materials often requires specialized techniques.

    Purpose of the Study:

    • To introduce a novel method for detecting the handedness of chiral materials using linearly polarized light.
    • To explore the application of Second Harmonic Generation (SHG) microscopy in chiral nanostructure analysis.

    Main Methods:

    • Utilized Second Harmonic Generation (SHG) microscopy.
    • Investigated G-shaped planar chiral nanostructures fabricated from gold.
    • Analyzed the spatial arrangement of SHG response hotspots.

    Main Results:

    • Demonstrated that the arrangement of SHG hotspots is dependent on the handedness of the chiral nanostructures.
    • Identified distinctive hotspots as key indicators of chirality.
    • Successfully detected material handedness using linearly polarized light.

    Conclusions:

    • The developed SHG microscopy technique offers a new pathway for studying chirality in artificial materials.
    • This method provides a sensitive way to probe the handedness of nanostructures.
    • Opens new avenues for the characterization and design of chiral metamaterials.