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Updated: Jun 26, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 17, 2013
Halothane-induced alteration in the fluidity of rat brain synaptosomal membranes and its relationship to anesthesia
B V Sastry1, J J Franks, M J Surber
1Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6600.
Abstract:
Concentrations of halothane 1.43% or higher abolished the pain response and induced anesthesia. Halothane increased membrane fluidity of synaptosomes and microsomes both at non-anesthetic and anesthetic concentrations. Changes in fluidity in synaptosomes did not return to control levels even after the animals recovered from anesthesia. Alteration in membrane fluidity by halothane is a non-selective effect and may not play a definitive role in anesthesia.
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