Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

Behavioral Genetics and Its Designs

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

Introduction to Epidemiology

Introduction to Epidemiology

Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Principles of Pharmacogenetics: Types of Genetic Variants

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Maternal Cesarean Section and Offspring ASD or ADHD Risk: A Nurses' Health Study II Analysis.

American journal of epidemiology·2026

Same author

Leveraging <i>cis-</i> and <i>trans-</i> variants to improve protein expression level prediction for proteome-wide association studies.

bioRxiv : the preprint server for biology·2026

Same author

Identification of multi-omic pleiotropy factors for peripheral artery disease.

Human molecular genetics·2026

Same author

LANTERN: Leveraging Local Ancestry Tracts to Enhance Rare-Variant Aggregate Association Testing.

medRxiv : the preprint server for health sciences·2026

Same author

Association of genetic variants in the autophagy gene ATG4B with asthma.

medRxiv : the preprint server for health sciences·2026

Same author

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits.

Nature communications·2026

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Five classic articles in genetic epidemiology.

Andrew T DeWan¹

¹Yale School of Public Health, New Haven, Connecticut 06520-8034, USA. andrew.dewan@yale.edu

The Yale Journal of Biology and Medicine

|July 1, 2010

Summary

Genetic epidemiology advances our understanding of inherited diseases by mapping genetic factors. New sequencing technologies accelerate the discovery of genetic causes of illness across populations.

Area of Science:

Genetic epidemiology
Population genetics
Disease genetics

Background:

Understanding the genetic basis of inherited diseases is crucial.
Genetic epidemiology investigates the role of genetic factors in disease occurrence within populations.
Familial aggregation of diseases provides clues to genetic influences.

Observation:

Significant progress has been made in mapping numerous genetic loci linked to Mendelian and complex diseases.
Technological advancements in high-throughput, low-cost sequencing are revolutionizing genetic research.
These innovations enable more comprehensive analysis of genetic inheritance patterns.

Findings:

Key publications have profoundly influenced the methodologies and conceptual frameworks in population-scale genetic studies.

More Related Videos

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

Related Experiment Videos

Last Updated: Jun 11, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

The field is rapidly evolving, driven by discoveries in genetic loci and sequencing capabilities.

Current research focuses on unraveling complex genetic architectures of diseases.

Implications:

Future research will likely identify more genes contributing to various diseases.
Advances in genetic epidemiology will enhance our ability to predict, prevent, and treat diseases.
Understanding population genetics is key to personalized medicine and public health strategies.