De novo synthesis and lectin binding studies of unsaturated carba-pyranoses
Timo Leermann1, Oliver Block, Michael A L Podeschwa
1Bergische University Wuppertal, Gaussstrasse 20, 42097, Wuppertal, Germany. timo.leermann@broteleermann.de
Abstract:
Starting from branched para-benzoquinones a practical and highly flexible route is described for the preparation of unsaturated carbapyranoses. The potential of the synthesized galactose analogues to act as competitive inhibitors in lectin-carbohydrate interactions is investigated by means of Surface Plasmon Resonance (SPR) Spectroscopy.
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