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Complications among premature neonates treated with beractant and poractant alfa

Manizheh Mostafa Gharehbaghi1, Seddigheh Hossein Pour Sakha, Mortaza Ghojazadeh

  • 1Department of Neonatology and Pediatrics, Tabriz University, Medical Sciences, Tabriz, Iran. gharehbaghimm@yahoo.com

Indian Journal of Pediatrics
|July 1, 2010
PubMed

Insights

Poractant (curosurf) surfactant reduced intubation duration in preterm infants with Respiratory Distress Syndrome (RDS) compared to beractant (Survanta). However, no significant differences were found in oxygen therapy, hospitalization, or overall mortality and morbidity.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Clinical Trials

Background:

  • Respiratory Distress Syndrome (RDS) is a common condition in preterm infants.
  • Exogenous surfactant therapy is a standard treatment for RDS.
  • Different natural surfactant preparations exist, necessitating comparative studies.

Purpose of the Study:

  • To compare the safety and efficacy of poractant (curosurf) versus beractant (Survanta) in preterm infants with RDS.
  • To evaluate complications and clinical outcomes associated with two different natural surfactant treatments.

Main Methods:

  • A randomized clinical trial involving 150 preterm infants diagnosed with RDS.
  • Infants were randomized to receive either poractant (n=79) or beractant (n=71).
  • Primary outcome was duration of intubation; secondary outcomes included mortality and specific morbidities.

Main Results:

  • The mean duration of intubation was significantly shorter in the poractant group (3.13 days) compared to the beractant group (4.06 days) (p=0.05).
  • No significant differences were observed in the mean duration of oxygen therapy or hospitalization between the two groups.
  • Mortality and major morbidities, including pulmonary hemorrhage, intraventricular hemorrhage (IVH), patent ductus arteriosus, sepsis, and bronchopulmonary dysplasia, showed no significant differences.

Conclusions:

  • Poractant administration resulted in a shorter duration of intubation for preterm infants with RDS compared to beractant.
  • There was no significant superiority of poractant over beractant regarding oxygen therapy duration, hospitalization, or overall mortality and morbidity.
  • Both natural surfactant preparations appear to be safe and effective for RDS management in preterm neonates.
Abstract

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