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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Respiratory syncitial virus in children with acute respiratory infections

R Hemalatha1, G Krishna Swetha, M Seshacharyulu

  • 1Department of Microbiology, National Institute of Nutrition, Jamia-Osmania, Hyderabad, India. rhemalathanin@yahoo.com

Indian Journal of Pediatrics
|July 1, 2010
PubMed

Insights

Respiratory Syncytial Virus (RSV) infection is linked to bronchiolitis in young infants. Higher levels of Interleukin-8 were observed in RSV-positive children, indicating a strong inflammatory response.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Nutritional Science

Background:

  • Respiratory Syncytial Virus (RSV) is a common cause of acute respiratory infections in infants.
  • Nutritional status and its impact on RSV infection severity require further investigation.

Purpose of the Study:

  • To investigate the nutritional status of children diagnosed with Respiratory Syncytial Virus (RSV) infection.
  • To analyze the association between RSV infection and clinical manifestations like bronchiolitis, pneumonia, and upper respiratory tract infections (URTI).

Main Methods:

  • 126 children aged 4-24 months with acute respiratory infections were assessed for RSV.
  • Nasopharyngeal aspirates were collected for RSV detection and cytokine analysis (ELISA).
  • Clinical data including URTI, bronchiolitis, and pneumonia prevalence were recorded.

Main Results:

  • 46.66% of children tested positive for RSV.
  • RSV was more prevalent in children with bronchiolitis compared to URTI and pneumonia.
  • Elevated levels of Interleukin-2 and Interleukin-8 were found in RSV-positive children, decreasing after 5 days.

Conclusions:

  • RSV is frequently associated with bronchiolitis in younger infants, particularly those with normal birth weight.
  • Pro-inflammatory cytokine Interleukin-8 (IL-8) is significantly elevated in the nasopharyngeal aspirates of children with RSV infection.
Abstract

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