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Updated: Jun 11, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Periorificial and acral dermatitis in a newborn having milk intolerance
1Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. ehon@cuhk.edu.hk
Indian Journal of Pediatrics
|July 1, 2010
Summary
This case highlights a 2-week-old infant with diarrhea, metabolic acidosis, and a distinctive rash. Prompt zinc replacement resolved symptoms, underscoring the importance of screening for zinc deficiency in infants.
Area of Science:
- Pediatrics
- Nutritional Science
- Dermatology
Background:
- A 36-week premature infant presented with gastrointestinal and metabolic disturbances upon formula feeding.
- Initial sepsis and metabolic disease workup yielded negative results, suggesting an alternative diagnosis.
Observation:
- Recurrent diarrhea and metabolic acidosis occurred with formula reintroduction.
- A characteristic erythematous rash developed on the palms, feet, perioral, and perineal areas.
Findings:
- Laboratory confirmation of zinc deficiency.
- Complete resolution of rash and normalization of metabolic parameters following zinc supplementation.
Implications:
- Zinc deficiency should be considered in infants presenting with unexplained diarrhea, metabolic acidosis, and specific dermatological manifestations.
- Early diagnosis and treatment of zinc deficiency are crucial for infant well-being and preventing recurrent symptoms.
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