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Hormonal actions during oocyte maturation influence fertilization and early embryonic development
D T Armstrong1, X Zhang, B C Vanderhyden
1Department of Physiology, University of Western Ontario, London, Canada.
Annals of the New York Academy of Sciences
|January 1, 1991
Summary
Hormones are crucial for in vitro maturation (IVM) of mammalian oocytes, enhancing fertilization and developmental competence. Cumulus cells and specific hormones like FSH, progesterone, estradiol, and prolactin play vital roles, with species-specific variations.
Area of Science:
- Reproductive Biology
- Developmental Biology
- Endocrinology
Background:
- In vitro maturation (IVM) is a key technique in assisted reproduction.
- Understanding hormonal requirements is essential for optimizing oocyte developmental competence.
Purpose of the Study:
- To summarize the hormonal requirements for mammalian oocyte IVM, fertilization, and developmental competence.
- To elucidate the roles of specific hormones and cellular factors in oocyte maturation.
Main Methods:
- Review of existing evidence on hormonal influences during IVM.
- Analysis of the effects of FSH, steroids, and other hormones on oocyte maturation and fertilization.
- Examination of the role of cumulus cells and their secreted factors.
Main Results:
- Nuclear maturation occurs spontaneously, but cumulus cells are necessary for competence.
- FSH enhances fertilization and stimulates steroidogenesis; progesterone can substitute for FSH in rats.
- Estradiol and prolactin show species-specific synergistic effects with FSH.
Conclusions:
- Hormonal and cellular factors significantly impact mammalian oocyte IVM, fertilization, and developmental potential.
- Further research is needed to clarify mechanisms and species-specific roles for broader applications in animal production and human health.
Keywords:
AmericasAustraliaBiologyCanadaClinical ResearchDeveloped CountriesEmbryoEndocrine SystemFertilizationFollicle Stimulating HormoneGonadotropinsGonadotropins, PituitaryHormonesIn VitroLuteinizing HormoneNorth AmericaNorthern AmericaOceaniaPhysiologyPregnancyReproductionResearch MethodologySummary Report