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Related Concept Videos

Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
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Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
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Published on: March 15, 2024

Treating depression and oppositional behavior in adolescents.

Rachel H Jacobs1, Emily G Becker-Weidman, Mark A Reinecke

  • 1Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
|July 1, 2010
PubMed
Summary
This summary is machine-generated.

Treating adolescent depression with fluoxetine, alone or with cognitive behavior therapy (CBT), effectively reduces oppositional behaviors. Antidepressant medication showed greater improvements in oppositionality compared to non-medication treatments.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Behavioral Psychology
  • Clinical Psychology

Background:

  • Adolescents with depression and high oppositionality present complex treatment challenges.
  • Limited research exists on treatment outcomes for youth with co-occurring internalizing (depression) and externalizing (oppositionality) problems.
  • Oppositionality in depressed youth can complicate therapeutic interventions.

Purpose of the Study:

  • To investigate the impact of fluoxetine, cognitive behavior therapy (CBT), their combination, and placebo on oppositional behavior in depressed adolescents.
  • To determine if treatments targeting depression also alleviate co-occurring oppositional symptoms.
  • To compare the efficacy of medication, therapy, and combined treatments for reducing oppositionality.

Main Methods:

  • A randomized controlled trial involving depressed adolescents.
  • Comparison of four treatment groups: fluoxetine, CBT, fluoxetine + CBT, and placebo.
  • Assessment of oppositionality levels at baseline and after 12 weeks of treatment.

Main Results:

  • All treatment groups demonstrated a decrease in oppositionality over 12 weeks.
  • Adolescents receiving fluoxetine (alone or with CBT) showed significantly greater reductions in oppositionality compared to those not on antidepressant medication.
  • Fluoxetine-based treatments were more effective in reducing oppositional behavior than CBT or placebo alone.

Conclusions:

  • Treatments aimed at alleviating depression in adolescents can effectively reduce co-occurring oppositional behavior.
  • Antidepressant medication, specifically fluoxetine, plays a significant role in mitigating oppositionality in depressed youth.
  • Combined fluoxetine and CBT may offer a comprehensive approach to treating comorbid depression and oppositionality in adolescents.