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Updated: Jun 11, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
A high circulating copy number of HHV-6 due to chromosomal integration in a child with acute lymphoblastic leukemia
Olli Lohi1, Mikko Arola, Irmeli Lautenschlager
1Pediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland. olli.lohi@uta.fi
Abstract:
We report a case of a 3.5-year-old female with a very high copy number of human herpesvirus 6 (HHV-6) detected by PCR in blood during acute lymphoblastic leukemia induction therapy. The patient was unsuccessfully treated with antiviral drugs. HHV-6 genome was shown to be constitutively integrated into chromosome 22q-tel, likely to be inherited from the mother who was found to carry high HHV-6 copy number. This case highlights the importance of excluding HHV-6 chromosomal integration before diagnosing HHV-6 infection or reactivation in immunocompromised patients.
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