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Updated: Jun 11, 2026

Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies
Published on: December 15, 2014
Corticospinal tract dysfunction and development of amyotrophic lateral sclerosis following electrical injury
William Huynh1, Amanda Lam, Steve Vucic
1Multidisciplinary Motor Neuron Disease Clinical Service, Institute of Neurological Sciences, Prince of Wales Hospital, Randwick, New South Wales, Australia.
Abstract:
The causal relationship between electrical injury and development of amyotrophic lateral sclerosis (ALS) remains controversial. We describe the case of a 25-year-old man who developed ALS after a severe electrical injury. Cerebral magnetic resonance imaging (MRI) demonstrated hyperintensities involving the corticospinal tract. Functional testing with transcranial magnetic stimulation established that the motor cortex was relatively inexcitable. In addition, there were features of denervation on electromyography and muscle biopsy that supported concomitant lower motor neuron findings and the diagnosis of ALS.
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