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Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Primary Motives: Sleep, Sex, and Pain Avoidance01:24

Primary Motives: Sleep, Sex, and Pain Avoidance

Primary motives such as sleep, sex, and pain avoidance are crucial drivers of behavior in humans and animals. These motives ensure survival, reproductive success, and overall well-being by prompting actions that meet essential bodily needs.
Sleep is a fundamental physiological drive that fosters a state of restfulness crucial for several bodily functions. It facilitates body restoration, the process by which the body repairs, rejuvenates, and maintains itself during sleep, including memory...
Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

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Related Experiment Video

Updated: Jun 11, 2026

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

Pain relief is a human right.

Michel Daher1

  • 1Department of Surgery, Saint George Hospital, University Medical Center, Beirut, Lebanon. mndaher@inco.com.lb

Asian Pacific Journal of Cancer Prevention : APJCP
|July 2, 2010
PubMed
Summary

Effective pain management remains a critical public health issue, with many patients receiving inadequate relief. Advocating for pain relief as a fundamental human right is essential for improving patient care and quality of life.

Area of Science:

  • Medical Ethics
  • Public Health
  • Pain Management

Background:

  • Historically, medical treatment prioritized life-saving over pain amelioration.
  • A significant gap exists between understanding pain pathophysiology and its effective treatment.
  • Chronic pain is a widespread public health problem affecting cancer and HIV/AIDS patients.

Purpose of the Study:

  • To highlight the global undertreatment of pain.
  • To advocate for pain relief as a fundamental human right and public health imperative.
  • To promote policy reform and legislative changes for improved pain management.

Main Methods:

  • Review of epidemiological evidence on chronic pain prevalence and undertreatment.
  • Analysis of existing declarations and actions by national and international bodies.

More Related Videos

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

Related Experiment Videos

Last Updated: Jun 11, 2026

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

  • Proposal of essential legislative components for pain management rights and duties.

    • Main Results:

    • Up to 50% of cancer patients receive inadequate pain relief.
    • 60%-100% of HIV/AIDS patients experience pain during their illness.
    • A paradigm shift is needed from viewing pain management as good practice to an imperative based on patient rights.

    Conclusions:

    • Pain relief is a critical component of medical ethics and a fundamental human right.
    • Legislation is needed to ensure reasonable pain management, physician accountability, and accessible expertise.
    • Promoting palliative care and reforming statutes are crucial for dignified suffering and improved quality of life.