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Updated: Jun 11, 2026
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Review of published information on foam sclerotherapy
Markus Stücker1, Stephan Kobus, Peter Altmeyer
1Department of Dermatology and Vascular Surgery, Vein Centre-Ruhr-University Bochum, St Maria-Hilf-Hospital, Bochum, Germany. m.stuecker@derma.de
Background:
New data on foam sclerotherapy of varicose veins has been recently published.
Objective:
To identify the current treatment modalities and their effectiveness in use of foam sclerotherapy.
Materials And Methods:
Review of the recent literature regarding clinical treatment of varicose veins using foam sclerotherapy, with emphasis on safety and efficacy. RESULTS Foam sclerotherapy of the great saphenous vein is more effective than liquid. Higher sclerosant concentrations tend to induce higher occlusion. Catheter-assisted sclerotherapy may further improve occlusion rates. To achieve adequate occlusion, vein diameter and volume of foam must be matched. If a critical foam volume is exceeded, the risk of deep venous thrombosis increases. Foam sclerotherapy offers the possibility of using lower sclerosant concentrations than with liquids. Foam sclerotherapy can also be used in venous malformations and periulcerous tributaries. Side effects are hyperpigmentation, skin necrosis, scotoma, and thromboembolic events. Thromboembolism prophylaxis is necessary only in patients with special risk factors.
Conclusion:
Foam sclerotherapy has significantly better efficacy than liquid. It is essential to select the correct concentration and the correct foam volume. In the hands of an experienced physician, foam sclerotherapy is a safe and effective option for treating varicose veins.
