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Serum selenium concentrations in rheumatoid arthritis.

J R O'Dell1, S Lemley-Gillespie, W R Palmer

  • 1University of Nebraska Medical Center, Omaha 68198-2265.

Annals of the Rheumatic Diseases
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

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Low serum selenium concentrations were observed in patients with rheumatoid arthritis compared to healthy individuals. This suggests selenium may play a role in rheumatoid arthritis development or progression.

Area of Science:

  • Biochemistry
  • Immunology
  • Nutritional Science

Background:

  • Selenium is an essential trace element vital for glutathione peroxidase, an enzyme protecting cells from oxidative stress.
  • Selenium exhibits antiproliferative, anti-inflammatory, antiviral, and immune-modulating properties.
  • Oxidative damage and immune dysregulation are implicated in rheumatoid arthritis pathogenesis.

Purpose of the Study:

  • To investigate serum selenium concentrations in patients with seropositive rheumatoid arthritis.
  • To compare selenium levels between rheumatoid arthritis patients, fibrositis patients, and healthy controls.
  • To explore the potential role of selenium in rheumatoid arthritis development and progression.

Main Methods:

  • Serum selenium concentrations were measured in 101 patients with seropositive rheumatoid arthritis.

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  • Selenium levels were also measured in 29 healthy controls and 8 patients with fibrositis.
  • Statistical comparison of mean serum selenium concentrations between the groups.

    • Main Results:

    • Serum selenium concentrations were significantly lower in rheumatoid arthritis patients (mean (SD) 148 (42) micrograms/l) compared to healthy controls (160 (25) micrograms/l).
    • Rheumatoid arthritis patients also had lower selenium levels than patients with fibrositis (166 (25) micrograms/l).
    • A notable difference was observed between rheumatoid arthritis patients and both control groups.

    Conclusions:

    • Lower serum selenium concentrations are associated with seropositive rheumatoid arthritis.
    • Selenium may influence the impact of infections or genetic factors in rheumatoid arthritis development.
    • Further research is warranted to elucidate the precise role of selenium in rheumatoid arthritis pathogenesis and progression.