Related Experiment Video
Updated: Jun 11, 2026
07:18
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Published on: June 13, 2019
TMSG-1 and its roles in tumor biology
Xiao-Yan Xu1, Fei Pei, Jiang-Feng You
1Peking University Health Science Center Department of Pathology, School of Basic Medical Sciences, Beijing 100191, PR China.
Chinese Journal of Cancer
|July 2, 2010
Summary
Tumor Metastasis Suppressor Gene 1 (TMSG-1) inhibits cancer invasion and metastasis by promoting apoptosis. Its precise mechanism involving vacuolar H+-ATPase and ceramide requires further exploration.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Tumor metastasis suppressor gene 1 (TMSG-1) is a newly identified gene.
- TMSG-1 plays a critical role in suppressing tumor cell invasion and metastasis.
- Its function is linked to promoting apoptosis in tumor cells.
Purpose of the Study:
- To review the discovery and structure of TMSG-1.
- To elucidate the roles of TMSG-1 in inhibiting tumor invasion and metastasis.
- To explore the potential mechanisms underlying TMSG-1's function.
Main Methods:
- Literature review of existing studies on TMSG-1.
- Analysis of TMSG-1 protein structure.
- Discussion of proposed mechanisms involving vacuolar H+-ATPase and ceramide.
Main Results:
- TMSG-1 demonstrates significant tumor metastasis suppressor activity.
- Potential mechanisms involve interactions with vacuolar H+-ATPase and ceramide pathways.
- Research on TMSG-1 is currently limited, with ongoing studies in Shanghai and by the authors' group.
Conclusions:
- TMSG-1 is a promising target for cancer metastasis research.
- Further investigation is needed to fully understand TMSG-1's molecular mechanisms.
- The discovery of TMSG-1 opens new avenues for therapeutic strategies against cancer metastasis.
Related Concept Videos
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...