Related Experiment Video
Updated: Jun 11, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
[Evaluation of the dose received by organs at risk]
A Mervoyer1, A Lisbonna, E Rio
1Service de Radiothérapie, Centre René-Gauducheau, CLCC Nantes Atlantique, Boulevard Jacques-Monod, 44805 Nantes Saint-Herblain cedex, France. augustinmervoyer@yahoo.fr
Abstract:
The arrival of new technologies and the increase of the possible planned treatments require tools to evaluate and compare the delivered dose to specific organs at risk. Among several options providing the same tumour control, the choice will be made in favour of those that best spare the organs at risk. The evaluation tools have to report acute and late complications, and to be simple to use. The evaluation of the delivered dose to specific organs at risk is currently based on dose-volume histograms, conformal index and the integral dose. However, many questions remain as to reducing the normal tissue toxicity: is it better to deliver a relatively lower dose over a large volume or a relatively higher dose over a smaller volume? The long-term clinical follow-up of patients remains necessary.
Related Concept Videos
Biological Effects of Radiation
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Drug Dosage Regimen: Overview
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Factors Affecting Drug Response: Overview
