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Neurons: The Axon

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Related Experiment Video

Updated: Jun 11, 2026

Deciphering Axonal Pathways of Genetically Defined Groups of Neurons in the Chick Neural Tube Utilizing in ovo Electroporation

Deciphering Axonal Pathways of Genetically Defined Groups of Neurons in the Chick Neural Tube Utilizing in ovo Electroporation

Published on: May 2, 2010

Cellular strategies of axonal pathfinding.

Jonathan Raper¹, Carol Mason

¹Department of Neurosciences, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104-6058, USA. raperj@mail.med.upenn.edu

Cold Spring Harbor Perspectives in Biology

|July 2, 2010

Summary

This review explores how pioneer neurons guide axon growth in the developing nervous system. It details the extracellular and cell surface environments, guidance cues, and receptors essential for precise axon pathfinding.

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Last Updated: Jun 11, 2026

Deciphering Axonal Pathways of Genetically Defined Groups of Neurons in the Chick Neural Tube Utilizing in ovo Electroporation

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Published on: May 2, 2010

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The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

Published on: October 30, 2014

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

Axon guidance is crucial for forming functional neural circuits.
The developing nervous system relies on precise axon trajectories.
Understanding axon pathfinding informs regenerative medicine.

Purpose of the Study:

To review the properties of pioneer neurons in early development.
To summarize knowledge of the substrates supporting axon growth.
To discuss guidance cues, receptors, and their expression in axon extension.

Main Methods:

Literature review of decades of research on axon guidance.
Analysis of studies on pioneer neuron development.
Synthesis of findings on extracellular and cell surface interactions.

Main Results:

Pioneer neurons establish initial axon pathways.
Extracellular and cell surface molecules provide guidance substrates.
Specific guidance cues and receptors mediate axon extension and target recognition.

Conclusions:

Axon pathfinding is a complex process involving pioneer neurons, substrates, and guidance cues.
Precise regulation of cue expression and receptor function is vital for neural circuit formation.
Further research into axon guidance mechanisms holds therapeutic potential for neural repair.